School of Medical Biological Sciences

Course Catalog

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The Biotechnology Graduate Program requires each student to take 7 core courses. These courses are designed to give students the academic foundation necessary to understand the theory behind a wide variety of techniques used in today’s biotechnology laboratory. The required labs that accompany each core course give students opportunities to gain valuable training with the equipment and techniques actually used in the biotech industry. In addition to the core courses, several additional courses are required for graduation and each student chooses two electives to gain specialized knowledge in more specific areas of interest.

Symbols used: * Core Course, # Required Course

BIOT 5101 & BIOT 6101 #Biotechnology Research Seminar (1 CH)
Students will present their thesis research progress to faculty and peers. Each student enrolled in BIOT 5331, BIOT 5332, BIOT 6331 or BIOT 6332 must present his/her research each semester enrolled as scheduling permits. The student should have a committee meeting following the seminar. Seminars are formal PowerPoint presentations in preparation for a thesis defense.

BIOT 5131 Critical Reading I (1 CH)
This course is the first of a two-course sequence that introduces the early graduate student to primary literature, the basic organization of scientific papers, and how to identify the questions being addressed based on the scientific method. Students will learn how to read and interpret methodologies and results published by other scientists. This course will provide the student with a thorough understanding of the strengths and limitations of scientific writing. The class is presented in a discussion format to help students develop their critical reading and analytical thinking skills.

BIOT 5132 Critical Reading II (1 CH)
The second of a two-course sequence that introduces the early graduate student to primary literature and helps them develop critical reading and analytical thinking skills. This course is taught at a higher level than Critical Reading I and focuses on critiquing and developing opinions on scientific articles. Although this is the second of a two-course sequence, the first course (Critical Reading I) is not a prerequisite. This course is team taught with a different instructor facilitating the discussion each week on a topical paper of choice. Students read and evaluate the methods and results presented in published papers. The class is presented in a discussion format.

BIOT 5140 Emerging Technologies (1 CH)
Independent study and presentation of an emerging technique or technology in the field of biotechnology. Students will develop skills in researching and evaluating techniques used in research; learn to find and understand pertinent scientific information; develop technical writing skills; and develop skills in preparing and giving oral presentations.

BIOT 5211 *Advanced Biotechniques (2 CH)
An introduction to standard molecular biology techniques such as isolation and purification of proteins and nucleic acids, cloning and expression of recombinant proteins; with laboratory component. Co-requisite BIOT 5211L.

BIOT 5211L *Advanced Biotechniques Laboratory (2 CH)
Hands-on training in fundamental laboratory procedures and instrumentation used in recombinant DNA and protein technology. Practical lab-bench experience, record keeping and data presentation is emphasized. Co-requisite BIOT 5211.

BIOT 5221 *Proteins and Nucleic Acids (2 CH)
The goal of the course is to provide a critical understanding of the relationship between structure and function of biological macromolecules such as proteins and nucleic acids. Topics covered include the molecular basis for eukaryotic inheritance; structure and function; chromosomal organization; DNA replication and repair, transcription and translation; the genetic code, regulation of gene expression, genetic differentiation; genetic manipulation. Co-requisite BIOT 5221L.

BIOT 5221L *Proteins and Nucleic Acids Laboratory (2 CH)
The goal of the course is to provide a critical understanding of the relationship between structure and function of biological macromolecules such as proteins and nucleic acids. The Lab component of this course will give the students hands-on experience in using molecular modeling programs to learn how to manipulate protein structures, performing docking simulations, and graphically display proteins and nucleic acids structures. Co-requisite BIOT 5221.

BIOT 5222 *Advanced Metabolism (2 CH)
The primary objective of this course is for the student to gain an understanding of the metabolic processes in bacteria, plants and animal cells and how metabolism is affected by enzymes, substrates, other metabolites and by bio-production of commercial products. Theoretical aspects of enzymatic reaction mechanisms; mechanisms of inhibitors and fermentation technology. Co-requisite BIOT 5222L.

BIOT 5222L *Advanced Metabolism Laboratory (2 CH)
The laboratory experiments will allow students to gain experience in metabolic assays and enzyme kinetic assays. Laboratory training also involves the preparation of a particular enzyme or other protein product by small pilot fermentation technology. Co-requisite BIOT 5222.

BIOT 5300 Introduction to Biotechnology (3 CH)
Hands-on experience with fundamental techniques of the biotechnology industry. These techniques will be presented within the scheme of prokaryotic gene manipulation and expression of protein products. The techniques will include gene manipulation, gene cloning, DNA purification and analysis, gene expression, protein quantification & analysis, and PCR.

BIOT 5310 #Fundamentals of Biomedical Research (3 CH)
Designed for students desiring research projects directed by UT Health Northeast faculty, to provide an orientation into the research laboratory workplace, master fundamental laboratory techniques, develop skills in planning a laboratory project, and present their work in both an oral and written context.

BIOT 5312 *Molecular Biochemistry (3 CH)
Application of molecular genetics to transcription control mechanisms; gene expression, molecular cloning, and applications to biotechnology.

BIOT 5331 Advanced Graduate Studies I
(1-3 CH)
Research hours spent under the supervision of a research advisor. The student begins an in-depth study of a particular scientific focus with a literature review of the area, a justification study of a project and mastery of fundamental laboratory techniques necessary for the research study. Students work with their research advisor to plan a thesis project and write a thesis proposal. Each hour of course credit translates into a minimum of three hours of lab work per week.

BIOT 5332 Advanced Graduate Studies II (1-3 CH)
Continuation of research hours spent under the supervision of a research advisor. Each hour of course credit translates into a minimum of three hours of lab work per week.

BIOT 6311 *Advanced Techniques in Molecular Biology (3 CH)
Lab-based course. The topics covered in this course will include gel electrophoresis for analysis of proteins and nucleic acids; radiochemistry; DNA and RNA synthesis, isolation, cloning, and sequencing; RFLP; expression of proteins; and restriction enzyme analysis.

BIOT 6312 *Advanced Techniques in Protein Chemistry (3 CH)
Lab-based course. This course covers protein chemistry, immunology, the techniques of preparing tissue cultures, physical biochemistry, receptors and receptor assays, microscopy, computational biotechnology, molecular modeling, and the biometric analysis of data at an advanced level.

BIOT 6334 Advanced Immunology (3 CH)
Advanced survey of the immune system with focus on human and mouse models. Origin and differentation of the hematopoietic system, antibody structure/function, innate and adaptive immunity responses to infection.

BIOT 6335 Tissue Culture (3 CH)
Lab-based course. Hands-on learning of techniques and proper care, management, handling, propagation and freezing of cell lines.

BIOT 6336 Biophysical Chemistry (3 CH)
Lab-based course. Instrumental analysis of proteins, nucleic acids, carbohydrates, and lipids. Methods to include ultracentrifugation; gradient separation of proteins and nucleic acids; UV/Visible spectroscopy; electrochemistry of cytochromes; X-ray diffraction of proteins and nucleic acids; and HPLC of proteins.

BIOT 6340 DNA Forensics (3 CH)
Forensic DNA analysis will provide students an understanding of the science of DNA analysis in criminal investigation. Students will gain an understanding of the history of forensic DNA analysis, sample collection and storage, DNA extraction, quantitation, amplification and separation, STR marker analysis, and analysis of non-autosomal DNA including mitochondrial DNA, Y-chromosome DNA, and X-chromosome DNA.

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