Research

Dasgupta, Santanu, Ph.D.

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Education:

  • PhD in Cancer Biology, Chittaranjan National Cancer Institute, India.
  • Postdoctoral Fellowship: Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine.

Research Interest:

Breast Cancer, Mitochondrial Genomics, Cancer Biomarkers.

Current Projects:

  • Characterization of key molecular genetic alterations in Breast Cancer.
  • Defining the role of miRNAs and mitochondrial genetic alteration in Breast Cancer.

Awards:

  • 2002-Scholar-In-Training Award from American Association for Cancer Research.
  • 2007- Scholar-In-Training Award from American Association for Cancer Research.
  • 2008-US-Egypt Joint Science and Technology Award.
  • 2011- A.D. Williams Award, Virginia Commonwealth University.
  • 2012- Elsa U Pardee Foundation Award.

Professional Affiliation:

American Association of Cancer Research

Lay Summary:

Breast cancer is the most common malignancy among women worldwide, causing half a million death annually. Invasive ductal carcinoma of the milk duct (IDC) represents up to 90% of all the breast cancers. Abnormal expression of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER) and progesterone receptor (PR) has been linked to a subset of breast cancers. However, an increasing number of patients do not express HER2, ER or PR and are known as triple negative breast cancer (TNBC). TNBCs are highly aggressive, untreatable by hormone or ani-HER2 therapy, and overall have a poor survival. The genetic alterations behind TNBC development and progression are not well understood. Our goal is to understand the molecular mechanism(s) of TNBC with a view to develop suitable TNBC management strategies.

Research Overview:

Endophilins are a family of proteins involved in clathrin mediated endocytosis, frequently altered in various cancers and implicated in biomarker development. One of the endophilins was found to be frequently altered in triple negative breast cancer and appeared to be involved in the regulation of cancer progression. Our laboratory is examining its potential role in triple negative breast cancer. We are also examining the potential role of miRNAs and mitochondrial energy reprogramming in triple negative breast cancer.

Selected Publications:

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