Kurdowska, Anna K., Ph.D.
1986, Ph.D. Biochemistry, Jagiellonian Univ., Cracow, Poland
1980, M.S. Biochemistry, Jagiellonian Univ., Cracow, Poland
Innate immunity and inflammatory response; Inflammatory response in the lung and other organs related to the acute lung injury / acute respiratory syndrome (ALI/ARDS), infection with influenza virus (flu), tuberculosis, and atherosclerosis. ALI/ARDS can be described as a complex clinical syndrome that results in significant impairment of lung function.
- Regulation of innate immunity in lung inflammation.
- Neutrophils, endothelial, and epithelial cells in the lung - activation and apoptosis.
- IgG receptors (FcgammaRs), TLR4, and other pro-inflammatory receptors - regulation and signaling.
One of the possible mechanisms underlying an inflammatory disease, such as ALI/ARDS, is excessive recruitment of white blood cells, neutrophils (PMNs) to lungs or other organs. PMNs, the most abundant white cells in circulation, play a central role in the defense system of the host. Typically, PMNs migrate to affected areas where they, for example, inactivate microorganisms. On the other hand, the excessive release of various pro-inflammatory mediators by PMNs may result in host tissue injury.
Our laboratory studies mechanisms underlying regulation of pro-inflammatory activities of neutrophils. Most current work is aimed at using unique models of ALI/ARDS, including influenza virus induced ALI, to evaluate contribution of cross talk between neutrophils and endothelial cells to the pathogenesis of these conditions. In parallel efforts, potential modulators of signaling pathways evoked by neutrophil - endothelial cross talk are being tested in several animal models (ALI/ARDS, influenza, and atherosclerosis) and in vitro systems. Understanding regulatory role that these pathways play during development of the inflammatory response will facilitate discovery of novel therapeutic agents.
Selected Papers and Abstracts:
- Allen TC, Kurdowska A. Interleukin 8 and Acute Lung Injury. Arch Pathol Lab Med. 2013 Jun 19. [Epub ahead of print].
- Stephenson K, Neuenschwander PF, Kurdowska AK. The effects of compounded bioidentical transdermal hormone therapy on hemostatic, inflammatory, immune factors; cardiovascular biomarkers; quality-of-life measures; and health outcomes in perimenopausal and postmenopausal women. Int J Pharm Compd. 2013 Jan-Feb;17(1):74-85.
- Krupa A, Fudala R, Florence JM, Tucker T, Allen TC, Standiford TJ, Luchowski R, Fol M, Rahman M, Gryczynski Z, Gryczynski I, Kurdowska AK. Bruton’s tyrosine kinase mediates cross-talk between FcγRIIa and TLR4 signaling cascades in human neutrophils. Am. J. Respir. Cell Mol. Biol., 48:240-249, 2013.
- Komissarov A, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen T, Idell S, Matthay M, Kurdowska A. Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin. Am. J. Physiol. Lung Cell. Mol. Physiol., 303:L1037-L1045, 2012.
- Gil S, Farnand AW, Altemeier WA, Gill SE, Kurdowska A, Krupa A, Matute-Bello G. Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury. Respiratory Research, 13:91, 2012.
- Fudala R., Rich R., Mukerjee A., Ranjan AP, Vishwanatha JK., Kurdowska AK., Gryczynski Z., Borejdo J, Gryczynski I. Fluorescence detection of MMP-9.II. Ratiometric FRET-based sensing with dually labeled specific peptide. Current Pharmaceutical Biotechnology, 2012 Feb 20.
- Sever-Chroneos Z, Murthy A., Davis J, Florence JM., Kurdowska A., Krupa A., Tichelaar JW, White MR., Hartshorn KL, Kobzik L., Whitsett JA, Chroneos ZC. GM-CSF modulates pulmonary resistance to influenza A infection. Antiviral Research 92:319-328, 2011.
Kurdowska A, Krupa A. Blockade of interleukin-6 in murine sepsis revisited: is there an indication for a new therapy in human patients? Crit. Care Med. 39:1582-1583, 2011.
- Wu Z, Sawamura T, Kurdowska AK, Ji HL, Idell S, Fu J. LOX-1 Deletion Improves Neutrophil Responses, Enhances Bacterial Clearance, and Reduces Lung Injury in a Murine Polymicrobial Sepsis Model. Infect. Immun. 79:2865-2870, 2011.
- Fudala R, Allen TC, Krupa A, Cagle PT, Nash S, Gryczynski Z, Gryczynski I, Kurdowska AK. Increased levels of nuclear factor κB and Fos-related antigen 1 in lung tissues from patients with acute respiratory distress syndrome. Arch Pathol Lab Med. 135:647-654, 2011.
- Fudala R, Krupa A, Stankowska D, Allen TC, Kurdowska AK. Does activation of the FcgammaRIIa play a role in the pathogenesis of the acute lung injury/acute respiratory distress syndrome? Clin. Sci. (Lond). 118:519-526, 2010.
- Kurdowska AK, Krupa A, Fudala R. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Shock 33:106; author reply 106-7. 2010.
- Komissarov AA, Mazar AP, Koenig K, Kurdowska AK, Idell S. Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits. Am. J. Physiol. Lung Cell. Mol. Physiol. 297:L568-L577. 2009.