Shams, Homayoun, D.V.M., Ph.D.
- Basic mechanisms of innate immune responses to protect against influenza and secondary bacterial pneumonia.
- Immunobiology and molecular pathogenesis of infectious diseases.
- Novel mechanisms of innate immunity to protect host against influenza virus and secondary bacterial pneumonia.
- Effect of second hand cigarette smoke on immunity against and influenza and secondary bacterial pneumonia.
The emergence of new microbial pathogens such as avian influenza virus, drug-resistant pathogens and the threat of bioterrorism are clear indications that infectious diseases will remain an enormous threat to the public health in the 21st century. A concerted scientific effort is required to deal with this ongoing problem.
Influenza virus causes several thousand deaths worldwide each year, despite the widespread use of vaccines. In the United States, 5-20% of the population develop influenza, more than 200,000 people are hospitalized from its complications, and about 36,000 people die annually (http://www.cdc.gov/flu/). Influenza also causes seasonal epidemics and rare pandemics that have killed up to 50 million persons in 1918 pandemic. These pandemics are regarded as inevitable and there is growing concern that avian influenza strains have the potential to cause the next pandemic. A critical public health priority is to develop strategies to reduce the morbidity and mortality from such events. Despite the widespread use of vaccines, influenza causes significant morbidity and mortality throughout the world, and improved methods to protect against influenza are sorely needed, particularly in the face of an impending pandemic.
Selected Papers and Abstracts:
- Guo J, Feng Y, Barnes PF, Huang FF, Idell S, Su DM, Shams H. Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging. PLoS ONE, 2012; 7(4):e34681.
- Huang F-F, Barnes PF, Feng Y, Donis R, Chroneos ZC, Idell S, Allen T, Perez DR, Whitsett JA, Dunussi-Joannopoulos K, Shams H. GM-CSF in The Lung Protects Against Lethal Influenza Infection. American Journal Of Respiratory and Critical Care Medicine, Volume 184, Number 2, July 2011, 259-268.
- Feng Y, Kong Y, Barnes PF, Huang F-F, Klucar P, Wang X, Samten B, Sengupta M, Machona B, Donis R, Tvinnereim AR, Shams, H. Exposure to Cigarette Smoke Inhibits the Pulmonary T cell Response to Influenza and Mycobacterium tuberculosis. Infection and Immunity, 2011 Jan;79(1):229-37.
- Barnes PF, Samten B, Shams H, Vankayalapati R. Progress in understanding the human immune responses to Mycobacterium tuberculosis. Tuberculosis (Edinb). 2009 Dec;89 Suppl 1:S5-9.
- Klucar P, Barnes PF, Kong Y, Howard ST, Pang X, Huang F-F, Tvinnereim AR, Samten B, Shams H, Vaccination Strategies to Enhance Local Immunity and Protection Against Mycobacterium tuberculosis. Vaccine, 2009, 12(27): 1816–1824.
- Wang X, Barnes PF, Dobos-Elder KM, Townsend JC, Chung Y, Shams H, Weis SS, Samten B, ESAT-6 inhibits production of interferon-gamma by M. tuberculosis-responsive human T cells. Journal of Immunology, 2009 Mar 15;182(6):3668-77.
- Klucar P, Barnes PF, Kong Y, Samten B, Tvinnereim A, Spallek R, Nepom GT, Singh M, Shams H. 2008. Characterization of effector functions of human peptide-specific CD4+ T cell clones for an intracellular pathogen. Human Immunology, 2008 Aug;69(8):475-83.
- Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. 2008. Evasion of peptide, but not lipid antigen presentation though pathogen- induced dendritic cell maturation. Proc Natl Acad Sci USA. 2008 Aug 12;105(32):11281-6.
- Samten B, Townsend J, Weis SE, Bhoumik A, Klucar P, Shams H, Barnes PF. 2008, CREB, ATF and AP-1 transcription factors regulate IFN-γ secretion by human t cells in response to microbial antigen. J Immunol. 2008 Aug 1;181(3):2056-64.
- Klucar P, Barnes PF, Kong Y, Samten B, Tvinnereim A, Spallek R, Nepom GT, Singh M, Shams H. 2008. Characterization of effector functions of human peptide-specific CD4+ T cell clones for an intracellular pathogen. Hum Immunol. 2008 Aug;69(8):475-83.
- Shams H, Klucar P, Weis SE, Lalvani A, Moonan PK, Safi H, Wizel B, Ewer K, Nepom GT, Lewinsohn DM, Andersen P, Barnes PF. Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles. J Immunol., 2004 Aug 1;173(3):1966-77.
- Shams H, Barnes PF, Weis SE, Klucar P, Wizel B. Human CD8+ T-Cells Recognize Epitopes of The 28 kDa Hemolysin and The 38 kDa Antigen of Mycobacterium tuberculosis. J Leukoc Biol. 2003 Dec;74(6):1008-14.
- Shams H , Wizel B, Lakey DL, Samten B, Vankayalapati R, Valdivia R, Kitchens RL, Griffith DE, Barnes PF. The CD14 Receptor Does Not Mediate Entry of Mycobacterium tuberculosis Into Human Mononuclear Phagocytes. FEMS Immunol Med Microbiol. 2003 May 15;36(1-2):63-69.
- Samten B, Wizel B, Shams H, Weis SE, Klucar P, Wu S, Vankayalapati R, Thomas EK, Okada S, Krensky AM, Barnes PF. CD40 ligand trimer enhances the response of CD8+ T-cells to Mycobacterium tuberculosis. J Immunol., 2003 Mar 15;170(6):3180-6.