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Research

Shetty, Sreerama, Ph.D.

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Contact: sreerama.shetty@uthct.edu

Research Interest:

Regulation of Gene Expression.
Tumor Metastasis and Fibrinolysis during lung injury and remodeling.

Current Projects:
Posttranscriptional regulatory mechanism of urokinase and its receptor expression. Mechanisms of urokinase-mediated cellular transformation and invasion.

Research Overview:

Disordered fibrin turnover has been implicated in the pathogenesis of a wide spectrum of lung diseases. The urokinase-urokinase receptor system has, in particular, been linked to altered fibrin clearence in the context of inflammation and repair as well as neoplasia in the lung parenchyma. Urokinase and its receptor govern the transformation of surrounding host tissues. The mechanisms involve regulation of their expression at the posttranscriptional level. We are studying how expression of components of fibrinolysis (urokinase, urokinase receptor and plasminogen activator inhibitors) and tumor suppressor proteins lead to cellular transformation and propagation of neoplasms in the lung.

Selected Papers and Abstracts:

Shetty S, Idell S. (2003) Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells. Am J Respir Cell Mol Biol. 2003 Jun 19 [Epub ahead of print].
Shetty S, Khalil B, Cines DB, Idell S. (2003) Regulation of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells. J. Biol. Chem. 278:18124-18131.
Shetty S, Penduthiri U, Halady PKS, Azghani A, Idell S. (2002) Urokinase induces its own expression in Beas2B lung epithelial cells. Am. J. Physiol. (Lung Cell. Mol. Physiol.) 283:L319-l328.
Shetty S. (2002) Cytoplasmic-nuclear shuttling of urokinase mRNA binding protein regulates message stability. Mol. Cell. Biochem. 237:55-67.
Gheath A, Shetty S, Idell S, Xue Y, Kitson RP, Halady PKS, Goldfarab RH. (2002) IL-2-mediated upregulation of uPA and uPAR in Natural Killer Cells. Biochem. Biophys. Res. Commun. 292: 184-189.
Shetty S, Idell S. (2001) Urokinase induces expression of its own receptor in Beas2B lung epithelial Cells. J. Biol. Chem. 276:24549-24556.
Shetty S, Idell S. (2000) Posttranscriptional regulation of urokinase mRNA: identification of a novel urokinase mRNA binding protein in human lung epithelial cells. J. Biol. Chem. 275:13771-13779.
Shetty S, Idell S. (2000) Posttranscriptional regulation of plasminogen activator inhibitor-1 in human lung carcinoma cells in vitro. Am. J. Physiol. (Lung Cell Mol. Physiol.) 278:L148-L156.

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University of Texas Health Center at Tyler

Research

Shetty, Sreerama, Ph.D.

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