Research

Tang, Hua, Ph.D.

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Contact: hua.tang@uthct.edu

Education:
1993, Ph.D. Biochemistry, Shanghai Medical University, China.
1994 – 1999, Postdoctoral Fellow in Biochemistry, Vanderbilt University, Nashville, TN.

Research Interest:

Protein kinases and phosphatases; Angiogenesis; Lung injury and fibrosis.

Current Projects:

  • Protein kinase D family kinases in angiogenesis.

Protein kinase D family kinases in lung injury and fibrosis.

Research Overview:

The serine/threonine protein kinase D (PKD) family kinases include PKD1, PKD2 and PKD3. PKD contains a tandem repeat of zinc finger-like cysteine-rich motifs at its N terminus that display high affinity for diacylglycerol or phorbol ester, a pleckstrin homology domain, and a C-terminal catalytic domain that shares homology with the calmodulin-dependent kinases. PKD family kinases can be activated by various pro-angiogenic, pro-inflammatory, and pro-fibrogenic agonists. By using the advanced technologies in molecular biology and biochemistry, we have recently identified that PKD family kinases are critical regulators of angiogenesis and lung injury. Thus, the long-term goals of our research are to determine the specific roles of PKD isoforms in angiogenesis and lung injury and fibrosis in vitro and in vivo, including the identity of PKD-targeted genes and protein substrates in endothelial and epithelial cells.


Selected Papers and Abstracts:

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