Research

Wallace, Richard, M.D.

← BACK  



Contact: richard.wallace@uthct.edu

Research Interest:
Mycobacteria; Nocardia

Research Overview:

  • The use of DNA fingerprinting using pulsed field gel electrophoresis and PCR techniques such as random amplified polymorphic DNA (RAPD) PCR to separate individual strains as a tool for studies of the epidemiology and transmission of infections due to the nontuberculous mycobacteria as well as Mycobacterium tuberculosis.
  • Drug susceptibilities and the use of drugs other than sulfonamides for therapy of the opportunistic pathogen nocardia. Relationship of drug susceptibility patterns in this species to taxonomic grouping. Use of PCR for rapid species identification.
  • Development of new drugs, better standardized methods of susceptibility testing, defining the mechanisms and genetics of drug resistance in the rapidly growing mycobacteria (i.e., M. fortuitum, M. chelonae, M. abscessus). Clinical correlation of the results of therapy with susceptibility results. Characterization of a new species of mycobacteria associated with hypersensitivity pneumonitis in association with metal grinding.
  • Taxonomy (recognition and characterization) of new pathogenic (i.e. disease producing) species of rapidly growing mycobacteria and nocardia. The use of DNA fingerprinting using pulsed field gel electrophoresis and PCR techniques such as random amplified polymorphic DNA (RAPD) PCR to separate individual strains as a tool for studies of the epidemiology and transmission of infections due to the nontuberculous mycobacteria as well as Mycobacterium tuberculosis. Previous studies have resulted in the naming of 4 new species, including Mycobacterium mucogenicum , Mycobacterium goodii , Mycobacterium wolinskyi , and Nocardia pseudobrasiliensis.

Selected Papers and Abstracts:

NOTICE: Protected health information is subject to electronic disclosure.