Dr. Galina Florova graduated with a Master’s Degree in Microbial Engineering from the Moscow Technological Institute of Food Industry and completed a Ph.D. in Genetics at the Institute for Genetics and Selection of Industrial Microorganisms in Moscow, Russia. She continued her training as a postdoctoral fellow at the University of Maryland and Virginia Commonwealth University, later working as a Research Assistant Professor at Virginia Commonwealth University and Portland State University. Dr. Florova joined the faculty at the University of Texas Health Science Center at Tyler in 2009 and is currently serving as an Associate Professor in the Department of Cellular and Molecular Biology. Her scientific interest in basic and translational research is supported by a broad background in cell and molecular biology, working with animal models— including a rabbit model of empyema, and overall extensive experience in bacterial genetics and physiology. Dr. Florova has co-authored more than 45 publications, and her research is currently funded by the NIH.

Education and Training

Moscow Technological Institute of Food Industry
M.S. Microbial Engineering 1976-1981
Institute for Genetics and Selection of Industrial Microorganisms
Ph.D. Genetics (Biology) 1988- 1992
University of Maryland
Postdoctoral Fellow Biochemistry 1995-1997
Virginia Commonwealth University
Postdoctoral Fellow Medicinal Chemistry 1997-1999

Research Interests

Molecular mechanisms of fibrinolysis in vivo
Increasing the efficacy of fibrinolytic therapy
Bioanalytic approaches to personalized therapy
Genetics of Streptomyces sp. and chemistry of natural compounds

Courses Taught

Biotechnology Master’s Program, University of Texas Health Science Center at Tyler
Course Coordinator: BIOT 5221
Team Lecturer: BIOT 5132, BIOT 5211/5211L, BIOT 5221, BIOT 5222/5222L, BIOT 6321
Graduate Student Mentor
Thesis Committee Member

Publication Highlights

Sillen M, Weeks SD, Zhou X, Komissarov AA, Florova G, Idell S, Strelkov SV, Declerck PJ. Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J Thromb Haemost. 2019 Dec 19. PMID: 31858714
Beckert L, Brockway B, Simpson G, Southcott AM, Lee YCG, Rahman N, Light RW, Shoemaker S, Gillies J, Komissarov AA, Florova G, Ochran T, Bradley W, Ndetan H, Singh KP, Sarva K, Idell S. Phase 1 trial of intrapleural LTI-01; single chain urokinase in complicated parapneumonic effusions or empyema. JCI Insight. 2019 Apr 18;5. PMID: 30998508
Surasarang SH, Sahakijpijarn S, Florova G, Komissarov AA, Nelson CL, Perenlei E, Fukuda S, Wolfson MR, Shaffer TH, Idell S, Williams RO 3rd. Nebulization of Single-Chain Tissue-Type and Single-Chain Urokinase Plasminogen Activator for Treatment of Inhalational Smoke-Induced Acute Lung Injury. J Drug Deliv Sci Technol. 2018 Aug; 48:19-27. PMID: 30123328
Fukuda S, Enkhbaatar P, Nelson C, Cox RA, Wolfson MR, Shaffer TH, Williams RO 3rd, Surasarang SH, Sawittree S, Florova G, Komissarov AA, Koenig K, Sarva K, Ndetan HT, Singh KP, Idell S. Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator. Clin Transl Med. 2018 Jun 18;7(1):17. PMID: 29916009
Komissarov AA, Rahman N, Lee YCG, Florova G, Shetty S, Idell R, Ikebe M, Das K, Tucker TA, Idell S. Fibrin turnover and pleural organization: bench to bedside. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L757-L768. Review. PMID: 29345198
Florova G, Azghani AO, Karandashova S, Schaefer C, Yarovoi SV, Declerck PJ, Cines DB, Idell S, Komissarov AA. Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L54-L68. PMID: 28860148