Dr. Komatsu received his PhD in Biological Science at the Hiroshima University. After receiving PhD degree, he worked as a postdoctoral fellow and scientist in the Department of Physiology at the University of Massachusetts Medical School and joined the faculty. Since receiving his PhD, he has been working in the fields of cell contractility and motility for many years. He has a strong expertise in the roles of myosin II molecules and its regulatory proteins in cell motile and contractile processes in vitro and in vivo. His researches have also been studied cellular phenotypic modulation in physiological and pathological processes such as atherosclerosis, asthma and fibrosis.

In 2013, he moved to University of Texas Health Science Center at Tyler. While here, he began studying diverse lung disease including lung fibrosis and asthma. Specifically, how of cell motility and contractility may play a role in these diseases.

Education and Training

1997-2002 Postdoctoral research fellow, Department of Physiology,
University of Massachusetts Medical School

1994-1997 Ph.D. Hiroshima University (Biological Science)

1992-1994 M.S. Tokyo University of Agriculture (Plant Pathology)

1988-1992 B.S. Tokyo University of Agriculture (Agriculture)

Courses Taught

BIOT 6312: Cell migration

BIOT 5222: Muscle Physiology

BIOT 5132: Critical Reading II

Research Interest

1. Understanding the mechanisms of cellular phenotypic transition associated with the development of fibrosis.

2. Understanding the role of ATF4 in to the development and progression of pleural fibrosis.

3. Understanding the mechanisms of phenotypic modulation of smooth muscle cells during the development of asthma and atherosclerosis.

Publication Highlights

1. Komatsu S, Fan L, Idell S, Shetty S, Ikebe M. Caveolin-1-Derived Peptide Reduces ER Stress and Enhances Gelatinolytic Activity in IPF Fibroblasts. Int J Mol Sci. 18;23(6):3316. (2022) PMID: 35328736

2. Komatsu S, Wang L, Seow CY, Ikebe M. p116Rip promotes myosin phosphatase activity in airway smooth muscle cells. J Cell Physiol. 235:114-127 (2020). PMID:31347175

3. Komatsu S, Kitazawa T, and Ikebe M. Visualization of stimulus-specific heterogeneous activation of individual vascular smooth muscle cells in aortic tissues. J. Cell. Physiol. 233, 434-446 (2018). PMID: 28295256