Dr. Tvinnereim is an Associate Professor of Cellular and Molecular Biology. She was trained as an Immunologist and Microbiologist at the Medical College of Wisconsin. Dr. Tvinnereim came to the University of Texas Health Science Center at Tyler as a postdoctoral fellow in 2002 and joined the faculty in 2007. Dr. Tvinnereim is the Director of Core Facilities and oversees common equipment used by our faculty to perform their research.

Education and Training

2002 - 2007 Senior Postdoctoral Fellow University of Texas Health Science Center at Tyler
1998 – 2002 Postdoctoral Fellow University of Iowa
1992 - 1998 Ph.D. Medical College of Wisconsin
1989 - 1992 B.S. Bradley University
1987 – 1989 A.S. Rock Valley College

Courses Taught

BIOT 6335 Tissue Culture
BIOT 6340 DNA Forensics
BIOT 6334 Advanced Immunology
BIOT 6336 Biophysical Chemistry
BIOT 5211 Advanced Biotechniques


Core Facility

Dr. Tvinnereim is responsible for the operation and management of designated core facility equipment and the BSL3 laboratory in Biomedical Research. The core facility of UT Tyler Health Science Center supports the innovative research done at UT Tyler Health Science Center by providing specialized equipment as well as expertise and training required to optimize the data obtained from this equipment. The core facility equipment includes flow cytometers, microCT scanners, a flexivent ventilator for mice, and an aerosol exposure chamber.

Selected Publications

2018
   Tripathi D., Cheekatla S.S., Paidipally P., Radhakrishnan R.K., Welch E., Thandi R.S., Tvinnereim A.R., Vankayalapati R. c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice. Sci Rep. 2018 Feb 19;8(1):3310
2018   Paidipally P., Tripathi D., Van A., Radhakrishnan R.K., Dhiman R., Venkatasubramanian S., Devalraju K.P., Tvinnereim A.R., Valluri V.L., Vankayalapati R. Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection. J Infect Dis. 2018 Mar 28;217(8):1323-1333
2017   Cheekatla S.S., Tripathi D., Venkatasubramanian S., Paidipally P., Welch E., Tvinnereim A.R., Nurieva R., and Vankayalapati R.: IL-21 Receptor Signaling is Essential for Optimal CD4+ T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice. J. Immunol. 199(8);2815-2822. 2017.
2007   Cortes, C., Rzomp, K.A., Tvinnereim, A., Scidmore, M.A., and Wizel, B.: Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with several Rab GTPases. Infect Immun. 75:5586-5597. 2007.
2007   Tvinnereim, A., and Wizel B.: CD8+ T cell protective immunity against Chlamydia pneumoniae includes an H2-M3-restricted response that is CD4+ T cell-independent. J. Immunol. 179:3947-57. 2007.
2005   Pinchuk, I., Starcher, B., Livingston, B., Tvinnereim, A., Wu, S., Appella, E., Sidney, J., Sette, A., and Wizel, B.: A CD8+ T cell heptaepitope minigene vaccine induces protective immunity against Chlamydia pneumoniae. J. Immunol. 174:5729-39. 2005.
2004   Tvinnereim, A., Hamilton, S.E., and Harty, J.T.: Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens. J. Immunol. 173:1994-2002. 2004
2000   Badovinac, V. P., Tvinnereim, A.R., and Harty, J.T.: Regulation of antigen-specific CD8+ T cell homeostasis by Perforin and IFN-. Science. 290(5495) 1354-1358. 2000
2000   Tvinnereim, A.R., and Harty, J.T.: CD8+ T cell priming against a non-secreted Listeria monocytogenes antigen is independent of the anti-microbial activities of IFN-. Infect. Immun. 68(4) 2196-2204. 2000.
2000    Harty, J.T., Tvinnereim, A.R., and White, D.W.: CD8+ T cell effector mechanisms in resistance to infection. Ann. Rev. Immunol. 18:275-308. 2000.