Biography

Buka Samten completed his medical education at Xinjiang Medical University and his MS degree in Immunology at Beijing University School of Health Sciences in Beijing, China. He had lectured immunology and experimental immunology to the medical school students and graduate students at these universities as an Assistant Professor after his graduations. In 1998, he had joined the research group at the Center for Pulmonary and Infectious Diseases at the University of Texas Health Science Center at Tyler (UTHCT) as a postdoctoral research fellow. Since then, he has conducted scientific research to understand the immune responses against tuberculosis infection. He was appointed as an Instructor of Microbiology and Immunology in 2002, Assistant Professor in 2006, and Associate Professor in 2009 at UTHCT.

His research has focused on understanding the defects in immune responses of tuberculosis patients by examining the intracellular proteins of T cells of tuberculosis patients. He has also studied the effects of major virulence factors of tuberculosis pathogen, Mycobacterium tuberculosis, on immune cells, such as T cells, dendritic cells, and macrophages. His research was supported by the funds from the Presidential Research Council of UTHCT, the Potts Memorial Foundation, and the grants from the National Institutes of Health. He has published over 60 research papers in peer-reviewed scientific journals, made numerous posters and oral presentations, and given invited talks at the national and international scientific meetings. He serves as an ad hoc grant reviewer for the American Heart Association and NIH study sections. He has also served as an ad hoc manuscript reviewer for several scientific journals in the field of infection and immunity.

He was awarded the Keystone Symposia Scholarship by the Keystone Symposia and Junior Faculty Travel Award and Laboratory Travel Grants by the American Association of Immunologists. His research interests include T cell immune responses against microbial pathogens, the interaction between Mycobacterium tuberculosis, the pathogen, and immune cells, and development of novel anti-tuberculosis drugs.

Education & Training

Xinjiang Medical University
MD - Medicine, 1981-1986
Beijing University School of Health Sciences
MS - Immunology, 1993-1996
University of Texas Health Science Center at Tyler
Postdoctoral - Immunology, 1998-2002

Research Interests

Interaction between host immune cells and the pathogen Mycobacterium tuberculosis
T cell immune responses against microbial pathogen
Novel anti-tuberculosis drug development targeting immune cells and microbial factors
Antigen presenting cells in infection

Courses Taught

Medical Microbiology and Immunology (medical school students and graduate students in China)
Critical Reading II (Biotech Master of Science Program at UTHCT)
Advanced Immunology (Biotech Master of Science Program at UTHCT)
Transgenic and gene knockout animal techniques (Biotech Master of Science Program at UTHCT)
Laser Capture Microdissection and Electrophoretic Mobility Shift Assay with labs as part of the Advanced Biotechnology Lectures (Biotech Master of Science Program at UTHCT)

Publish Highlights

Samten B, Wizel B, Shams H, Weis SE, Klucar P, Wu S, Vankayalapati R, Thomas EK, Okada S, Krensky AM, and Barnes PF. CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis. Journal of Immunology, 170, 3180-3186, 2003. Samten B, Howard ST, Weis SE, Wu S, Shams H, Townsend JC, Safi H, and Barnes PF. Cyclic AMP response element-binding protein positively regulates production of interferon-γ by T-cells in response to a microbial pathogen. Journal of Immunology, 174: 6357–6363, 2005. Samten B, Townsend JC, Weis SE, Bhoumick A, Klucar P, Shams H, and Barnes PF. CREB, ATF and AP-1 transcription factors regulate IFN-g secretion by human T cells in response to microbial antigen. Journal of Immunology, 181:2056-2064, 2008. Wang X, Barnes PF, Dobod-Elder KM, Townsend JC, Chung Y, Shams H, Weis SE, Samten B. ESAT-6 inhibits production of interferon-g by M. tuberculosis-responsive human T cells, Journal of Immunology, 182:3668-3677, 2009. Peng H, Wang X, Barnes PF, Tang H, Townsend JC, and Samten B. The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-g production through the p38 mitogen-activated protein kinase pathway. The Journal of Biological Chemistry, 286:24508-24518, 2011.