Dr. Guo has conducted biomedical research for more than 15 years, with excellent research experience in cell phenotypic regulation, gene transcriptional regulation, screening of signaling pathways/factors that mediate gene function, and generation of conditional knockout mice to examine the biological function of genes in specific tissues using animal models. Dr. Guo received her PhD in Physiology and Pharmacology at the University of Georgia in 2014. After graduation, she worked as a postdoctoral fellow and scientist in the Department of Physiology and Pharmacology at the University of Georgia.

In 2019, Dr. Guo joined the University of Texas Health Science Center at Tyler as an Assistant Professor in the Department of Cellular and Molecular Biology. She has published over 30 peer-reviewed papers in journals such as Circulation Research and Journal of Hepatology as the first author. Dr. Guo is also an active member of American Heart Association (AHA) since 2012. Dr. Guo’s research program has been continuously funded by the American Heart Association (AHA) and National Institutes of Health (NIH) since 2012.

Education & Training

• Assistant Research Scientist, The University of Georgia, 2019

• Postdoctoral Fellow, The University of Georgia, 2018

• PhD, The University of Georgia, Physiology and Pharmacology, 2014

• MS, Fudan University, Molecular Epidemiology of Tumor, China, 2007

• BS, Jining Medical College, Preventive Medicine, China, 2004

Research Interest

Dr. Guo’s research broadly focuses on understanding the novel molecules and mechanisms important for cardiovascular disease and/or metabolic disease development. These molecules may contribute to the prevention and/or generation of therapeutics of these human diseases. Specifically, we study 1) the vascular smooth muscle cell (SMC), endothelial cell (EC), and immune cell phenotypic change during the cardiovascular disease development including atherosclerosis, abdominal aortic aneurysm (AAA), hypertension, restenosis and so on; 2) the adipocyte, liver cell, and immune cell phenotypic change during the metabolic disease development including obesity, diabetes, hepatic steatosis and the related complications. Our laboratory uses multiple, cutting-edge approaches to identify novel targets and develop gene/cell-based therapeutics to treat these human problems.

• Vascular smooth muscle cell differentiation
• Vascular smooth muscle cell phenotypic modulation in vascular remodeling
• Endothelial cell inflammation and macrophage activation in atherosclerosis
• Epithelial-mesenchymal transition (EMT) in disease development
• Metabolic diseases including obesity, diabetes, and hepatic steatosis

Publication Highlights

Guo X, Adeyanju O, Sunil C, Mandlem V, Olajuyin A, Huang S, Chen SY, Idell S, Tucker TA, and Qian G. DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition. Am J Physiol Cell Physiol. 2022 May 18. PMID: 35584329.

Guo X, Sunil C, Adeyanju O, Parker A, Huang S, Ikebe M, Tucker TA, Idell S, and Qian G. PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways. Sci Rep. 2022 Feb 23;12(1):3053.

Qian G, Adeyanju O, Sunil C, Huang SK, Chen SY, Tucker TA, Idell S, and Guo X. Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet-Induced Obesity. Am J Pathol. 2022 Feb;192(2):226-238.

Qian G, Adeyanju O, Roy S, Sunil C, Jeffers A, Guo X, Ikebe M, Idell S, and Tucker TA. DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition. Am J Respir Cell Mol Biol. 2022 Feb;66(2):171-182.

Guo X, Li FF, Xu Z, Yin A, Yin H, Li C, and Chen SY. (2017). DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure. J Lipid Res. Sep;58(9):1777-1784.

Guo X, Shi N, Cui XB, Wang JN, Fukui Y, and Chen SY. (2015). Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling. Circ Res. 116(10):e71-80.

Guo X, Stice SL, Boyd NL, and Chen SY. (2013). A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells. Am J Physiol Cell Physiol. 15;304(4):C289-98.

Cui XB, Guo X, Chen SY. (2013). Response gene to complement 32-deficiency causes impaired placental angiogenesis in mice. Cardiovasc Res, 99(4):632-9.