Dr. Guohua Yi joined the faculty at the University of Texas Health Science Center at Tyler in September 2019. He completed his Ph.D. studies at Wuhan University, China, majoring in Molecular Virology. He then pursued his postdoctoral training at Rutgers University and at the Langone Medical Center of New York University. He then joined Texas Tech University Health Sciences Center as a junior faculty member. During that time, Dr. Guohua Yi had interests in immunopathogenesis, gene therapy and vaccine development for a variety of devastating viral diseases, such as HIV, Zika, and SARS-Cov. Currently, his research focuses on developing an applicable CRISPR-Cas9 in vivo delivery strategy for T cell and other immune cells gene editing, which may result in novel treatments for HIV, cancer and some autoimmune diseases. In addition, his lab’s research also includes development of a universal vaccine for HIV and influenza virus. Dr. Yi’s research has been funded by National Institute of Allergy and Infectious Diseases (NIAID) and National Heart, Lung, and Blood Institute (NHLBI), as well as Common Funds of the National Institutes of Health (NIH). Dr. Yi has published over 20 peer-reviewed journal papers and served as an ad hoc member for several NIH study sections.

Education and Training

Ph.D.: Wuhan University (Molecular virology)
Postdoctoral training: Rutgers University (Virology), New York University (Medical microbiology), Texas Tech University Health Sciences Center (Immunology).

Research Interest

Gene and cell therapy for infectious diseases and cancer treatments using targeted delivery of gene editing system;
Vaccine development for HIV, influenza and zika viruses;
Targeted phage therapy for treating drug-resistant bacterial infections, including Mycobacterium Tuberculosis.

Publication Highlights

Preeti Bharaj, Chunting Ye, Sean Petersen, Qianghu Wang, Baoli Hu, N. Manjunath, Premlata Shankar*, Guohua Yi*. (2018). Gene array analysis of PD-1H overexpressing monocytes reveals a pro-inflammatory profile. Heliyon. (Corresponding author).
Xuequn Xu, Sean Petersen, Cynthia M. Rodriguez, Guohua Yi*. (2018). PD-1H facilitates phagocytic clearance of HIV infected T cells by monocyte derived macrophages and dendritic cells. The Journal of Immunology. 200 (1 Supplement), 4. (Corresponding author).
Guohua Yi*, Xuequn Xu, Sojan Abraham, Nora Ortega, Premlata Shankar and Manjunath (2017) A DNA vaccine confers protection against Zika virus infection in humanized mice. (eBioMedicine, doi:10.1016/j.ebiom.2017.10.006) (Corresponding author).
Sojan Abraham, Hua Guo, Jang-Gi Choi, Chunting Ye, Nora Ortega, Guohua Yi, Midhun Ben Thomas, Alok Dwivedi, N Manjunath, Premlata (2017) Combination of IL-2 and IL-10 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in Humanized mice. Heliyon, 2017 Apr; 3(4): e00276. doi: 10.1016/j.heliyon.2017.e00276.
Guohua Yi*, Xiongying Tu, Preeti Bharaj, Hua Guo, Junli Zhang, Premlata Shankar, Manjunath (2015) Human Rhinovirus Presenting 4E10 Epitope of HIV-1 MPER Elicits Neutralizing Antibodies in Human ICAM-1 Transgenic Mice. Molecular Therapy, 2015 Oct;23(10):1663-70. doi: 10.1038/mt.2015.107. Epub 2015 Jun 10., Corresponding author).