Biography
My research experience spans diverse fields, e.g. cell and molecular biology, biophysics, physiology, and molecular toxicology. The fundamental aspects of the pathophysiology of diseases have motivated my research. I completed my training in veterinary medicine, but subsequently discovered my interests in public health. I received my doctoral degree in environmental and occupational health.
Training in Environmental Health: My research over the past 14 years has focused on nanotoxicology, a new field of molecular toxicology that includes projects addressing the safety and toxicological assessments of nanomaterials, the emerging environmental contaminants. I have been one of the leading contributors to several pioneering discoveries in this field. As my doctoral training progressed, I became more convinced of the need for new methods and tools for nanomaterial safety assessment.
My interest to develop novel models and technologies to study the health effects of the next generation engineered materials that require screening methodologies typically unavailable, along with endpoints not previously evaluated using current guidelines, led me to the Harvard School of Public Health, where I pursued my postdoctoral training.
At UTHSCT, I have been interested in developing high-throughput screening assays for evaluating the carcinogenic and fibrogenic potential of nanomaterials. We are in the process of developing a more extensive database of corona composition of a diverse nanoparticle library to help predict the effects and biokinetics of inhaled nanoparticulates
Education and Training
Sri Venkateshwara Veterinary University
Tirupati, India
V.Sc & A.H (1996-2001)
University of Pittsburgh
PhD (2006-2010)
Harvard
T.H. Chan School of Public Health
Post-Doctoral Research (2012-2018)
Courses Taught BIOT 5211: Advanced Biotechniques
BIOT 5132: Critical Reading II
Research Interests Despite overwhelming scientific evidence on the health effects of environmental pollutants, there are significant gaps in our knowledge of how to monitor exposures to complex toxic mixtures and their integrated effects. Further, currently, there is only a limited understanding of the underlying biology that governs toxic mixture-induced lung diseases.
Catching the pathological events early occurring under a stealth mode after exposures to hazardous agents is the biggest untapped opportunity to have a major impact on early detection and treatment of lung diseases. Our research focuses on exosomes, 30-140 nm extracellular vesicles (EVs) actively secreted by cells, to gain insight into these knowledge gaps. Our group is interested in examining the composition of the EVs and their predictive power to identify toxic mixtures of public health concern and to provide a snapshot of the health status of lungs. Publication Highlights https://www.ncbi.nlm.nih.gov/myncbi/1ZWPwzYOitycm8/bibliography/public/
Tsuda A, Donaghey TC, Konduru NV, Pyrgiotakis G, Van Winkle LS, Zhang Z, Edwards P, Bustamante JM, Brain JD, Demokritou P. Age-Dependent Translocation of Gold Nanoparticles across the Air-Blood Barrier.
ACS Nano. 2019 Aug 16. doi: 10.1021/acsnano.9b03019. [Epub ahead of print]
Molina RM, Konduru NV, Queiroz PM, Figueroa B, Fu D, Ma-Hock L, Groeters S, Schaudien D, Brain JD. Fate of Barium Sulfate Nanoparticles Deposited in the Lungs of Rats. Sci Rep. 2019 Jun 3;9(1):8163. doi: 10.1038/s41598-019-44551-2.
Konduru NV, Damiani F, Stoilova-McPhie S, Tresback JS, Pyrgiotakis G, Donaghey TC, Demokritou P, Brain JD, Molina RM. Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions.
Langmuir. 2018 Jun 5;34(22):6454-6461. doi: 10.1021/acs.langmuir.7b03741. Epub 2018 May 24.
Konduru NV, Molina RM, Swami A, Damiani F, Pyrgiotakis G, Lin P, Andreozzi P, Donaghey TC, Demokritou P, Krol S, Kreyling W, Brain JD. Protein corona: implications for nanoparticle interactions with pulmonary cells.
Part Fibre Toxicol. 2017 Oct 30;14(1):42. doi: 10.1186/s12989-017-0223-3.
Konduru NV, Murdaugh KM, Swami A, Jimenez RJ, Donaghey TC, Demokritou P, Brain JD, Molina RM. Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation.
Nanotoxicology. 2016 Aug;10(6):720-7. doi: 10.3109/17435390.2015.1113322. Epub 2015 Nov 19.
Tirupati, India
V.Sc & A.H (1996-2001)
University of Pittsburgh
PhD (2006-2010)
Harvard
T.H. Chan School of Public Health
Post-Doctoral Research (2012-2018)
Courses Taught BIOT 5211: Advanced Biotechniques
BIOT 5132: Critical Reading II
Research Interests Despite overwhelming scientific evidence on the health effects of environmental pollutants, there are significant gaps in our knowledge of how to monitor exposures to complex toxic mixtures and their integrated effects. Further, currently, there is only a limited understanding of the underlying biology that governs toxic mixture-induced lung diseases.
Catching the pathological events early occurring under a stealth mode after exposures to hazardous agents is the biggest untapped opportunity to have a major impact on early detection and treatment of lung diseases. Our research focuses on exosomes, 30-140 nm extracellular vesicles (EVs) actively secreted by cells, to gain insight into these knowledge gaps. Our group is interested in examining the composition of the EVs and their predictive power to identify toxic mixtures of public health concern and to provide a snapshot of the health status of lungs. Publication Highlights https://www.ncbi.nlm.nih.gov/myncbi/1ZWPwzYOitycm8/bibliography/public/
Tsuda A, Donaghey TC, Konduru NV, Pyrgiotakis G, Van Winkle LS, Zhang Z, Edwards P, Bustamante JM, Brain JD, Demokritou P. Age-Dependent Translocation of Gold Nanoparticles across the Air-Blood Barrier.
ACS Nano. 2019 Aug 16. doi: 10.1021/acsnano.9b03019. [Epub ahead of print]
Molina RM, Konduru NV, Queiroz PM, Figueroa B, Fu D, Ma-Hock L, Groeters S, Schaudien D, Brain JD. Fate of Barium Sulfate Nanoparticles Deposited in the Lungs of Rats. Sci Rep. 2019 Jun 3;9(1):8163. doi: 10.1038/s41598-019-44551-2.
Konduru NV, Damiani F, Stoilova-McPhie S, Tresback JS, Pyrgiotakis G, Donaghey TC, Demokritou P, Brain JD, Molina RM. Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions.
Langmuir. 2018 Jun 5;34(22):6454-6461. doi: 10.1021/acs.langmuir.7b03741. Epub 2018 May 24.
Konduru NV, Molina RM, Swami A, Damiani F, Pyrgiotakis G, Lin P, Andreozzi P, Donaghey TC, Demokritou P, Krol S, Kreyling W, Brain JD. Protein corona: implications for nanoparticle interactions with pulmonary cells.
Part Fibre Toxicol. 2017 Oct 30;14(1):42. doi: 10.1186/s12989-017-0223-3.
Konduru NV, Murdaugh KM, Swami A, Jimenez RJ, Donaghey TC, Demokritou P, Brain JD, Molina RM. Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation.
Nanotoxicology. 2016 Aug;10(6):720-7. doi: 10.3109/17435390.2015.1113322. Epub 2015 Nov 19.