- Xinxiang Medical University, MD
- Chinese Academy of Preventive Medicine, MS
- University of Kent, PhD
- University of Georgia, postdoctoral trainee
- University of Alabama at Birmingham, postdoc fellow
- Regulation of epithelial salt and fluid transport in the airways, the lungs, and kidney
- Stem cell therapy of acute lung injury, ARDS, IPF, and COPD
Epithelial sodium channel (ENaC) plays a critical role in airway mucus clearance and alveolar fluid clearance. Dysfunctional mucus/fluid clearance has been implicated in the pathogenesis of various critical pulmonary diseases/injuries, for instance, cystic fibrosis, pseudohypoaldosteronism type 1 (PHA-1), viral and bacterial pneumonia, influenza, occupational/environmental bronchitis, chronic obstructive pulmonary disease (COPD), and allergic respiratory disorders. ENaC as a major pathway for fluid resolution contributes up to 70% of lavage/fluid clearance. ENaC activity is regulated by post-translational modifications, including proteolysis and glycosylation. Our studies on the regulation of ENaC function in lung epithelium will provide novel information to our understanding of the pathogenesis, regeneration of edematous, fibric, and hypersecretive pulmonary diseases.